A reference human induced pluripotent stem cell line for large-scale collaborative studies.

C. Pantazis, A. Yang, E. Lara, J. McDonough, C. Blauwendraat, Li-Zhen Peng, H. Oguro, J. Kanaujiya, J. Zou, D. Sebesta, G. Pratt, E. Cross, J. Blockwick, P. Buxton, LB. Kinner-Bibeau, C. Medura, C. Tompkins, S. Hughes, M. Santiana, F. Faghri, M. Nalls, D. Vitale, S. Ballard, Y. Qi, DM. Ramos, KM. Anderson, J. Stadler, P. Narayan, J. Papademetriou, L. Reilly, MP. Nelson, S. Aggarwal, LU. Rosen, P. Kirwan, V. Pisupati, S. Coon, SW. Scholz, T. Priebe, M. Öttl, J. Dong, M. Meijer, LJM. Janssen, VS. Lourenço, R. van der Kant, D. Crusius, D. Paquet, A-C. Raulin, G. Bu, A. Held, B. Wainger, RMC. Gabriele, JM. Casey, S. Wray, D. Abu-Bonsrah, C. Parish, MS. Beccari, D. Cleveland, E. Li, ***IVL. Rose, M. Kampmann, CC. Aristoy, P. Verstreken, L. Heinrich, MY. Chen, B. Schüle, D. Dou, E. Holzbaur, M. Zanellati, R. Basundra, M. Deshmukh, S. Cohen, R. Khanna, M. Raman, ZS. Nevin, M. Matia, J. van Lent, V. Timmerman, B. Conklin, KJ. Chase, K. Zhang, S. Funes, DA. Bosco, L. Erlebach, M. Welzer, D. Kronenberg-Versteeg, G. Lyu, E. Arenas, E. Coccia, L. Sarrafha, T. Ahfeldt, J. Marioni, W. Skarnes, MR. Cookson, ME. Ward, F. Merkle

Cell Stem Cell, 2022

Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically‐induced and immune‐mediated mouse models of multiple sclerosis

HE. Titus, H. Xu, AP. Robinson, P. Patel, Y. Chen, D. Fantini, V. Eaton, M. Karl, ED. Garrison, ***IVL. Rose, M. Chiang, J. Podojil, R. Balabanov, S. Liddelow, RH. Miller, B. Popko, S. Miller

Glia, 2022

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

H. Kim, K. Leng, J. Park, A. Sorets, S. Kim, A. Shostak, RJ. Embalabala, Kate Mlouk, KA. Katdare, ***IVL. Rose, SM. Sturgeon, E. Neal, Y. Ao, S. Wang, M. Sofroniew, JM. Brunger, D. McMahon, MS. Schrag, M. Kampmann, E. Lippmann

Nature Communications, 2022

Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis.

K. Kleffman, G. Levinson, ***IVL. Rose, L. Blumenberg, S. Shadaloey, A. Dhabaria, E. Wong, F. Galán-Echevarría, A. Karz, D. Argibay, R. von Itter, A. Floristan, G. Baptiste, NM. Eskow, JA. Tranos, J Chen, EC. Vega y Saenz de Miera, ME. Call, R. Rogers, G. Jour, Y. Wadghiri, I. Osman, Y-M. Li, P. Mathews, R. Demattos, B. Ueberheide, K. Ruggles, SA. Liddelow, R. Schneider, E. Hernando

Cancer Discovery, 2022

CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states

K. Leng, ***IVL. Rose, H. Kim, W. Xia, W. Romero-Fernández, B. Rooney, M. Koontz, E. Li, Y. Ao, S. Wang, MC. Krawczyk, J. TCW, A. Goate, Y. Zhang, E. Ullian, M. Sofroniew, S. Fancy, MS. Schrag, E. Lippmann, M. Kampmann

Nature Neuroscience, 2022

mTOR controls neurotoxic lysosome exocytosis in inflammatory reactive astrocytes

B. Rooney, K. Leng, F. McCarthy, ***IVL. Rose, KA. Herrington, S. Bax, MY. Chin, S. Fathi, M. Leonetti, A. Kao, J. Elias, M. Kampmann

2021

Neuroinflammatory astrocyte subtypes in the mouse brain

P. Hasel, ***IVL. Rose, J. Sadick, RD. Kim, SA. Liddelow

Nature Neuroscience, 2021

Alterations in circulating extracellular vesicles underlie social stress‐induced behaviors in mice

S. Sakamoto, D. Mallah, DJ. Medeiros, E. Dohi, T. Imai, ***IVL. Rose, K. Matoba, X. Zhu, A. Kamiya, S-I. Kano

FEBS Open Bio, 2021

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

L. Barbar, T. Jain, M. Zimmer, I. Kruglikov, J. Sadick, M. Wang, K. Kalpana, ***IVL. Rose, S. Burstein, T. Rusielewicz, MP. Nijsure, KA. Guttenplan, A. di Domenico, G. Croft, B. Zhang, H. Nobuta, J. Hébert, SA. Liddelow, V. Fossati

Neuron, 2020

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia

K. Hartmann, D. Sepulveda-Falla, ***IVL. Rose, C. Madore, C. Muth, J. Matschke, O. Butovsky, SA. Liddelow, M. Glatzel, S. Krasemann

Acta Neuropathologica Communications, 2019

Glutathione S-transferases promote proinflammatory astrocyte-microglia communication during brain inflammation

S-I. Kano, EY. Choi, E. Dohi, S. Agarwal, DJ. Chang, AM. Wilson, BD. Lo, ***IVL. Rose, S. Gonzalez, T. Imai, A. Sawa

Science Signaling, 2019

Extracellular Vesicles for Research on Psychiatric Disorders

S-I. Kano, E. Dohi, ***IVL. Rose

Schizophrenia bulletin, 2018

Behavioral Changes in Mice Lacking Interleukin-33

E. Dohi, EY. Choi, ***IVL. Rose, A. Murata, S. Chow, M. Niwa, S-I. Kano

eNeuro, 2017